nonstationary | blog | publications | contact
Adrian Heilbut
contact
bio

I'm a PhD student in Bioinformatics at Boston University.

In the past, I worked in computational biology at MDS Proteomics and CombinatoRx. I did my undergraduate work in Computer Science and Neuroscience at the University of Toronto.

papers

Chiang C, Jacobsen JC, Ernst C, Hanscom C, Heilbut A, Blumenthal I, Mills RE, Kirby A, Lindgren AM, Rudiger SR, McLaughlan CJ, Bawden CS, Reid SJ, Faull RL, Snell RG, Hall IM, Shen Y, Ohsumi TK, Borowsky ML, Daly MJ, Lee C, Morton CC, Macdonald ME, Gusella JF, Talkowski ME.
Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration.
Nat Genet. 2012 Mar 4;44(4):390-7. PMID: 22388000
Talkowski ME, Ernst C, Heilbut A, Chiang C, Hanscom C, Lindgren A, Kirby A, Liu S, Muddukrishna B, Ohsumi TK, Shen Y, Borowsky M, Daly MJ, Morton CC, Gusella JF.
Next-generation sequencing strategies enable routine detection of balanced chromosome rearrangements for clinical diagnostics and genetic research
Am J Hum Genet. 2011 Apr 8;88(4):469-81 PMID: 21473983
Suzuki Y, Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehar J, Roth FP.
Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection
Nature Methods. 2011 Jan 9 (epub) PMID: 21217751
Lehar J, Krueger AS, Avery W, Heilbut AM, Johansen LM, Price ER, Rickles RJ, Short GF 3rd, Staunton JE, Jin X, Lee MS, Zimmermann GR, Borisy AA.
Synergistic drug combinations tend to improve therapeutically relevant selectivity.
Nat Biotechnology 2009 Jul;27(7):659-66. PMID: 19581876
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Mol Syst Biol. 2007 ;3(89). PMID: 17353931
Lehar J, Zimmermann GR, Krueger AS, Molnar RA, Ledell JT, Heilbut AM, Short GF 3rd, Giusti LC, Nolan GP, Magid OA, Lee MS, Borisy AA, Stockwell BR, Keith CT.
Chemical combination effects predict connectivity in biological systems.
Mol Syst Biol. 2007 ;3(80). PMID: 17332758
Bader GD, Heilbut A, Andrews B, Tyers M, Hughes T, Boone C.
Functional genomics and proteomics: charting a multidimensional map of the yeast cell.
Trends Cell Biol. 2003 Jul;13(7):344-56. Review. PMID: 12837605

Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, Yang L, Wolting C, Donaldson I, Schandorff S, Shewnarane J, Vo M, Taggart J, Goudreault M, Muskat B, Alfarano C, Dewar D, Lin Z, Michalickova K, Willems AR, Sassi H, Nielsen PA, Rasmussen KJ, Andersen JR, Johansen LE, Hansen LH, Jespersen H, Podtelejnikov A, Nielsen E, Crawford J, Poulsen V, Sorensen BD, Matthiesen J, Hendrickson RC, Gleeson F, Pawson T, Moran MF, Durocher D, Mann M, Hogue CW, Figeys D, Tyers M.
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Nature.2002 Jan 10;415(6868):180-3. PMID: 11805837
Cowan KN, Heilbut A, Humpl T, Lam C, Ito S, Rabinovitch M.
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nature Medicine. 2000 Jun;6(6):698-702.
PMID: 10835689